Cyclodextrin (CD) is a degradation product of starch which consists of cyclic oligosaccharide such as alpha, beta, gamma cyclodextrin with different size of cavity. In the area of complexation, cyclodextrin is the best contender where the “guest” molecule remains inside the host molecule. The determination of CD complex is successively achieved by phase solubility profile. Various methods are used to enhance the CD complexation such as Drug ionization, Salt formation, Complex-in-complex, Polymer complexes etc. The drug-cyclodextrin complex is found potential in improving various drug properties like improved solubility and dissolution profile of poorly soluble drugs, enhanced bioavaibility of drugs, improved the stability of drugs. This review article is spotlighted on the applications of and design of various cyclodextrin based novel drug delivery systems like Microspheres, Liposomes, Nanoparticle, Hydrogel, Micelles and Dendrimeres etc.
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